Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G q protein-induced cardiomyopathy
نویسندگان
چکیده
Valeriy Timofeyev, Cliff A. Porter, Dipika Tuteja, Hong Qiu, Ning Li, Tong Tang, Anil Singapuri, Pyung-Lim Han, Javier E. Lopez, H. Kirk Hammond, and Nipavan Chiamvimonvat Division of Cardiovascular Medicine, University of California, Davis, Department of Veterans Affairs, Northern California Health Care System, Mather, Department of Medicine, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, California; and Department of Neuroscience, Ewha Women’s University School of Medicine, Seoul, Korea
منابع مشابه
Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy.
Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy and progression to heart failure have been under intense investigation. Specifically, the salutary effects resulting from the disruption of AC(V) have been esta...
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Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP. The inhibition of adenylyl cyclase was carried out by measuring the ability of the macrophage chemotactic protein-1 to inhibit the forskolin-induced enzyme activity. Measurement of adenylyl cyclase activity was performed according to the procedure described by Wiegn. Adenylyl cyclase activity in the pres...
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β-Adrenergic receptor (β-AR) blockade is widely used to treat heart failure, since the adverse effects of chronic β-AR stimulation are central to the pathogenesis of this disease state. Transgenic (Tg) mice, where β-AR signaling is chronically enhanced by overexpression of cardiac β₂-ARs, is a surrogate for this mechanism, since these mice develop cardiomyopathy as reflected by reduced left ven...
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G protein-coupled receptor/adenylyl cyclase (AC)/cAMP signaling is crucial for all cellular responses to physiological and pathophysiological stimuli. There are nine isoforms of membrane-bound AC, with type 5 being one of the two major isoforms in the heart. Since the role of AC in the heart in regulating cAMP and acute changes in inotropic and chronotropic state are well known, this review wil...
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